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M94A3059.TXT
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1994-10-25
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Document 3059
DOCN M94A3059
TI CD5+/CD8+ percentage ratio: a new evolution predictive marker of HIV
infection.
DT 9412
AU Traina C; D'Alia G; Barone T; Centro AIDS, USL 58-Palermo, Italy.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):163 (abstract no. PB0078). Unique
Identifier : AIDSLINE ICA10/94369516
AB With reference to a study about the ratio CD5+/CD8+ as evolution marker
during HIV infection (Valguarnera e coll.), we studied 90 subjects HIV
infected in differents stages of disease (25 asymptomatics patients, 30
LAS, 20 ARC, 15 AIDS) and compared them with the homogeneous group of
healthy HIV negative subjects. The lymphocitic subpopulations were
studied with cytofluorimetric method using monoclonal antibodies (Ortho
Diagnostic System). We observed in HIV positive subjects, during the
disease the early gradual decrease of the percentage ratio CD5+/CD8+ and
also how this decrease maybe already demonstrated some weeks before
symptom onset. This observation allowed us to predict tho onset of the
LAS in 4 asymptomatics patients and the onset of the opportunistic
infection in 4 ARC patients. We are trying to confirm this observation
with a study on a bigger group of subjects, because the percentage ratio
CD5+/CD8+ could be, in the future, a very important help for the
diagnosis, prognosis and treatment in HIV infection.
DE Antigens, CD/*BLOOD Antigens, CD8/*BLOOD Biological Markers/BLOOD
Flow Cytometry Human HIV
Infections/CLASSIFICATION/DIAGNOSIS/*IMMUNOLOGY Leukocyte Count
Prognosis T-Lymphocyte Subsets/IMMUNOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).